LONGEVITY
AND THE 4 PRIMARY HALLMARKS OF AGING
The 4 Primary Hallmarks of Aging—nutrient sensing, microbiome, mitochondrial function, and chronic inflammation—are tightly interconnected. Dysregulation in one often leads to cascading effects that amplify the others, creating a vicious cycle that drives aging. Addressing these factors together (e.g., through dietary interventions, improving gut health, managing inflammation, and promoting mitochondrial function) is becoming a focus of aging research and anti-aging therapies.
Nutrient Sensing
Food is information that either turns on your longevity genes or killer genes depending on what you put in your mouth each day and is the key to a healthy microbiome. This is the primary cause of inflammation due to "insulin resistance"
Microbiome
You are only 10% human—90% of the cells in your body are mostly bacteria, viruses, and
parasites situated in your gut. Although these “gut buddies” can be affected by several factors, a healthy diet is the key to a healthy microbiome. The Gut-Brain Connection is the result of the many neurotransmitters and other signaling molecules made in the microbiome.
Mitochondria
In addition to making about 88 lbs of ATP of energy each day, the major function of mitochondria is as signaling molecules. Your mitochondria have mtDNA, i.e., mitochondrial DNA inherited from your mother that is different from your nDNA in your cells that was inherited from both parents. Both have developed together over the past 2 billion years—before any living life we know of had developed
Inflammation
Chronic inflammation (as distinct from acute inflammation, which is mostly a healing reaction) results because of mitochondrial dysfunction which effects the immune system, causing systemic inflammation and disease throughout the body.
Nutrient Sensing
Because our lifestyle makes up 80% of our health, nutrient sensing is influenced by our food choices and daily habits.
Microbiome
The gut microbiome is involved in nearly every aspect of health, enhancing digestion and boosting immunity.
Chronic Inflammation
Eliminating chronic inflammation reduces the risk of disease, improves immune function, and supports healthier aging.
Mitochondria
A healthy microbiome supports mitochondria, enhancing energy production, reducing oxidative stress, and improving cell repair.
4 PRIMARY HALLMARKS OF AGING THERAPEUTIC BUNDLES
The combination of these supplements addresses several primary hallmarks of aging, contributing to improved healthspan (the period of life spent in good health) and lifespan (the total length of life). Each supplement serves a specific purpose in maintaining or restoring bodily functions, cellular health, and overall vitality.
MEET
Graham Simpson MD
Dr. Graham Simpson is a globally renowned physician, founder, and medical director of Eternity Medicine, with over 40 years of experience in preventive and integrative medicine across five continents.
Board-certified in Internal Medicine, Anti-Aging Medicine, and Emergency Medicine, he has dedicated his career to pioneering personalized wellness programs that address the root causes of chronic diseases, particularly insulin resistance and metabolic disorders. A leading expert in reversing insulin resistance, Dr. Simpson combines cutting-edge diagnostics, advanced technologies, and integrative health approaches to optimize longevity and well-being
An accomplished author and sought-after speaker, he continues to inspire a global shift towards proactive, client-centered healthcare
